Beyond Binding: Precision CD3 Tools to Discover and Validate Functional Leads

Despite advances in T-cell redirecting therapies, a critical bottleneck persists: traditional recombinant CD3 proteins fail to recapitulate native conformation, often yielding non-functional antibody leads.

Kactus will present three distinct CD3 formats—traditional, VLP, and Nanodisc—each engineered to match the biological demands of a specific discovery stage, enabling reliable identification and validation of functional leads with translational relevance.