Comprehensive LC-MS/MS workflows for antibody drug conjugate (ADC) analysis

This session will present a streamlined and sensitive LC-MS workflow for 4 key quantitative pharmacokinetic/pharmacodynamic (PK/PD) assays using trastuzumab deruxtecan (TDx). Each of these assays provides unique insights into the behavior of the ADC, enabling a comprehensive PK/PD evaluation. Sensitivity and quantitative performance are critical for ADC analysis, enabling accurate and thorough assessments of drug stability, safety, and therapeutic efficacy. The session will highlight assay sensitivity and applicability to bioanalysis