Pioneer Antibody Discovery Platform

Pioneer Antibody Discovery Platform was developed for biotherapeutic antibody discovery by a group of highly experienced specialists at Bio-Rad. It delivers best-in-class biologic candidates (high affinity, excellent developability and diversity) in a short timeline. The platform includes a novel fully human synthetic Fab antibody library and a novel display system to deliver the following advantages: Size • One of the largest functional antibody phage display libraries with 225 billion unique antibodies. • High and diverse number of unique hits with broad epitope coverage. • Sub-nanomolar affinities directly from the library. Developability • Germline specific CDR design. • Sequence motifs causing developability issues were minimized. Speed • SpyDisplay, a novel proprietary selection platform, leads to fast and diverse selection of high-affinity candidate drugs. • Compatible with selection on cells. • Rapid affinity maturation process for ultra-high affinity selections. The Pioneer Antibody Discovery Platform delivers: • A great number of hits with diverse sequences after selection. • Over 20% of antibodies with sub-nanomolar affinities directly from the library. • Good developability parameters.