Drugging the unreachable: strategies for tissue-specific intracellular delivery

Talking Points

1. Biology

a. Many major drivers of cancer are located within the cell.

b. Small molecule vs large molecule dilemma:

Small molecule drugs that can access the intracellular space often lack tumor (or tissue) specificity.

Biologics that can specifically target tumors cells do not have easy access into the cytoplasm.

2. What drug delivery "vehicles" that can be employed to reach the tumor locale?

3. What strategies can be employed to increase specific delivery to the target tissue?

4. Enhancing cellular uptake and intracellular delivery: options

5. What are some applications for intracellular targeting of therapeutics?