Transforming Tumor Research: Engineering MHCs as Versatile Reagents

Transforming Tumor Research: Engineering MHCs as Versatile Reagents

Monday, April 15, 2024 3:00 PM to 3:20 PM · 20 min. (US/Pacific)
Cell Therapy
Presentation
Room 9

Information

  • In addressing solid tumors without specific biomarkers, the effectiveness of TCR-T cell therapy is hindered by the lack of reliable MHC reagents. 
  • To overcome this, we've developed versatile MHC molecules in different formats, such as peptide-ready, single-chain, and chimeric-MHC. These innovations offer convenient loading, enhanced sensitivity, and immunization capabilities. 
  • Our advancements, including fluorescent MHC-tetramers and MHC-VLPs, hold transformative potential in reshaping solid tumor studies by enabling more precise and effective R&D.

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