Pioneer Library and SpyLock: The Fastest Route to Mono- and Bi-Specific Therapeutic Antibodies

The Pioneer Antibody Discovery Platform is Bio-Rad’s new service for biotherapeutic discovery. The Pioneer Platform comprises a new antibody phage display library engineered to have optimal properties for the selection of therapeutic candidates, including the reduction of CDR-located posttranslational modification sites for improved developability. With 92% of the clones (VH and VL combined) encoding functional antibodies, the Pioneer Antibody Library encodes 2.25x1011 unique antibodies. Pioneer takes advantage of SpyDisplay, a novel selection system based on SpyTag technology and gives access to SpyLock, a novel prototyping tool for screening of bispecific antibodies. Herein, we demonstrate that the Pioneer Platform delivers diverse high-affinity antibody lead candidates. Using anti-TIGIT antibodies, we show that the performance of our lead candidates is comparable with antibodies undergoing clinical trials.